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Drugmakers have brought almost 450 orphan drugs to market and collected rich incentives by doing so. But nearly a third of the medicines aren't new or were repurposed many times for financial gain.

The unseeded Latvian shocked Simona Halep on Saturday, winning her first major in dramatic fashion. Ostapenko overcame dozens of unforced errors on the strength of a number of stunning shots.

President Trump called the GOP Secretary of state in Georgia the "enemy of the people." Democratic Rep. Lucy McBath, of Georgia's 6th District, disagrees.

We received over 6,000 entries to the Tiny Desk Contest. There was one winner, but there were many favorites. Here are a few more.

Rescue efforts continue in the city of Tainan, where a magnitude 6.4 quake struck early Saturday. News services report two of the dead are a baby and an adult man. Some 120,000 are without power.

Listener Sara Stasi plays the puzzle with puzzlemaster Will Shortz and NPR's David Folkenflik.

About 50 passengers were aboard the Red Line train when it left the Braintree station south of Boston about 6 a.m. Thursday.

The economy performed better than expected in the July-September period, after making a 4.6 percent jump in the second quarter of the year.

The flooding north of Chicago has affected some 6,800 buildings and is "unprecedented," Illinois officials said. It's expected to worsen this weekend.

Prosecutors said the denial of service attacks were not "victimless crimes." They estimated that it cost the companies attacked $5.6 million in extra staffing, software and loss in sales.